Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kit  KIT proto-oncogene receptor tyrosine kinase   (Synonyms: belly-spot, CD117, c-KIT, Dominant white spotting, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Steel Factor Receptor, Tr-kit)
Results	Reference
1	J:44143 Apelqvist A, Ahlgren U, Edlund H, Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol. 1997 Oct 1;7(10):801-4
1	J:116633 Beckett EA, Ro S, Bayguinov Y, Sanders KM, Ward SM, Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn. 2007 Jan;236(1):60-72
1	J:36230 Bernex F, De Sepulveda P, Kress C, Elbaz C, Delouis C, Panthier JJ, Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Development. 1996 Oct;122(10):3023-33
1	J:114702 Blanpain C, Lowry WE, Pasolli HA, Fuchs E, Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 2006 Nov 1;20(21):3022-35
1	J:182738 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK, Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13;22(3):651-9
1	J:135127 D'Autreaux F, Morikawa Y, Cserjesi P, Gershon MD, Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development. 2007 Jun;134(12):2237-49
1	J:81852 Doneda L, Klinger FG, Larizza L, De Felici M, KL/KIT co-expression in mouse fetal oocytes. Int J Dev Biol. 2002 Dec;46(8):1015-21
1	J:326362 Feng S, Li J, Wen H, Liu K, Gui Y, Wen Y, Wang X, Yuan S, hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells. Nat Commun. 2022 Jun 23;13(1):3588
1	J:333262 Feng S, Wen H, Liu K, Xiong M, Li J, Gui Y, Lv C, Zhang J, Ma X, Wang X, Yuan S, hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
1	J:253913 Guimaraes-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM, Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5
1	J:186529 He X, Yang WC, Wen XY, Tang D, Xiao L, Han J, Yu B, Zhang W, Mei F, Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence. Cells Tissues Organs. 2012;196(2):175-88
1	J:307968 He Y, Chen Q, Dai J, Cui Y, Zhang C, Wen X, Li J, Xiao Y, Peng X, Liu M, Shen B, Sha J, Hu Z, Li J, Shu W, Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
1	J:293102 Heinrich A, Potter SJ, Guo L, Ratner N, DeFalco T, Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Rep. 2020 Apr 14;31(2):107513
1*	J:24542 Hirata T, Kasugai T, Morii E, Hirota S, Nomura S, Fujisawa H, Kitamura Y, Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse. Brain Res Dev Brain Res. 1995 Apr 18;85(2):201-11
1	J:162252 Horiguchi S, Horiguchi K, Nojyo Y, Iino S, Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice. Biochem Biophys Res Commun. 2010 Jun 4;396(3):774-9
1	J:250152 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z, Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12;5:12982
1	J:303088 Iino S, Horiguchi S, Horiguchi K, Hashimoto T, Interstitial cells of Cajal in W(sh)/W(sh) c-kit mutant mice. J Smooth Muscle Res. 2020;56(0):58-68
1*	J:290712 Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko MSH, Araki K, Niwa H, MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. Dev Cell. 2020 Feb 24;52(4):429-445.e10
1	J:273748 Iskander SM, Feeney MM, Yee K, Rosenblum ND, Protein Kinase 2beta Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction. J Am Soc Nephrol. 2018 Apr;29(4):1198-1209
1*	J:202252 Jones RL, Pepling ME, KIT signaling regulates primordial follicle formation in the neonatal mouse ovary. Dev Biol. 2013 Oct 1;382(1):186-97
1	J:282136 Kato Y, Iwamori T, Ninomiya Y, Kohda T, Miyashita J, Sato M, Saga Y, ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. EMBO Rep. 2019 Dec 5;20(12):e48251
1*	J:322393 Kimura R, U Inoue Y, Kikkawa T, Tatehana M, Morimoto Y, Inada H, Oki S, Inoue T, Osumi N, Detection of REST expression in the testis using epitope-tag knock-in mice generated by genome editing. Dev Dyn. 2022 Mar;251(3):525-535
1*	J:192634 Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H, HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012 Nov;17(11):897-912
1	J:213984 Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H, HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012 Jun;17(6):439-54
1	J:195630 Krolewski RC, Packard A, Jang W, Wildner H, Schwob JE, Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One. 2012;7(12):e51737
1	J:258315 Langhorst H, Juttner R, Groneberg D, Mohtashamdolatshahi A, Pelz L, Purfurst B, Schmidt-Ott KM, Friebe A, Rathjen FG, The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice. Dis Model Mech. 2018 Feb 22;11(2):dmm032128
1*	J:317244 Lee J, Choi BI, Park SY, An SY, Han J, Kim JH, Fetal hematopoietic stem cells express MFG-E8 during mouse embryogenesis. Exp Mol Med. 2015 Jul 24;47:e174
1	J:340701 Lee SJ, Park J, Lee DJ, Otsu K, Kim P, Mizuno S, Lee MJ, Kim HY, Harada H, Takahashi S, Kim SJ, Jung HS, Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway. Cell Death Differ. 2021 May;28(5):1441-1454
1*	J:327630 Li R, Cai Y, Lin H, Dong L, Tang M, Lang Y, Qi Y, Peng Y, Zhou B, Yang G, Teng Y, Yang X, Generation of an Ihh-mKate2-Dre knock-in mouse line. Genesis. 2022 Jul;60(6-7):e23488
1	J:334438 Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP, Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013 Dec;1(6):604-19
1	J:224165 Lovasco LA, Gustafson EA, Seymour KA, de Rooij DG, Freiman RN, TAF4b is required for mouse spermatogonial stem cell development. Stem Cells. 2015 Apr;33(4):1267-76
1	J:337785 Lowenstein ED, Ruffault PL, Misios A, Osman KL, Li H, Greenberg RS, Thompson R, Song K, Dietrich S, Li X, Vladimirov N, Woehler A, Brunet JF, Zampieri N, Kuhn R, Liberles SD, Jia S, Lewin GR, Rajewsky N, Lever TE, Birchmeier C, Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. 2023 May 10;
1	J:194288 Manosalva I, Gonzalez A, Kageyama R, Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Dev Biol. 2013 Mar 15;375(2):140-51
1*	J:272572 May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM, Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 Nov 5;145(21):dev166363
1*	J:53330 Morohashi K, Tsuboi-Asai H, Matsushita S, Suda M, Nakashima M, Sasano H, Hataba Y, Li CL, Fukata J, Irie J, Watanabe T, Nagura H, Li E, Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Blood. 1999 Mar 1;93(5):1586-94
1	J:77350 Naito A, Yoshida H, Nishioka E, Satoh M, Azuma S, Yamamoto T, Nishikawa S, Inoue J, TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8766-71
1*	J:201080 Nelson DA, Manhardt C, Kamath V, Sui Y, Santamaria-Pang A, Can A, Bello M, Corwin A, Dinn SR, Lazare M, Gervais EM, Sequeira SJ, Peters SB, Ginty F, Gerdes MJ, Larsen M, Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013 May 15;2(5):439-47
1	J:44830 Ogura Y, Takakura N, Yoshida H, Nishikawa SI, Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta. Biol Reprod. 1998 Jan;58(1):65-72
1	J:70948 Osterlund C, Tohonen V, Forslund KO, Nordqvist K, Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation. Cancer Res. 2000 Feb 15;60(4):1054-61
1	J:168860 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE, Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug;28(8):1424-34
1	J:76669 Peters EM, Tobin DJ, Botchkareva N, Maurer M, Paus R, Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem. 2002 Jun;50(6):751-66
1	J:326088 Pogontke C, Guadix JA, Sanchez-Tevar AM, Munoz-Chapuli R, Ruiz-Villalba A, Perez-Pomares JM, Dynamic Epicardial Contribution to Cardiac Interstitial c-Kit and Sca1 Cellular Fractions. Front Cell Dev Biol. 2022;10:864765
1	J:269961 Radomska KJ, Coulpier F, Gresset A, Schmitt A, Debbiche A, Lemoine S, Wolkenstein P, Vallat JM, Charnay P, Topilko P, Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells. Cancer Discov. 2019 Jan;9(1):130-147
1	J:334500 Ruthig VA, Yokonishi T, Friedersdorf MB, Batchvarova S, Hardy J, Garness JA, Keene JD, Capel B, A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells. Biol Reprod. 2021 Apr 1;104(4):861-874
1	J:158290 Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
1	J:197538 Sasselli V, Boesmans W, Vanden Berghe P, Tissir F, Goffinet AM, Pachnis V, Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest. 2013 Apr 1;123(4):1763-72
1	J:87152 Saunders PT, Turner JM, Ruggiu M, Taggart M, Burgoyne PS, Elliott D, Cooke HJ, Absence of mDazl produces a final block on germ cell development at meiosis. Reproduction. 2003 Nov;126(5):589-97
1	J:308868 Senf K, Karius J, Stumm R, Neuhaus EM, Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium. Stem Cells. 2021 May;39(5):617-635
1	J:256730 Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S, MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. PLoS One. 2018;13(1):e0190800
1	J:227907 Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL, Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701
1	J:92510 Sumiyoshi H, Mor N, Lee SY, Doty S, Henderson S, Tanaka S, Yoshioka H, Rattan S, Ramirez F, Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone. J Cell Biol. 2004 Aug 16;166(4):591-600
1	J:288454 Sun G, Liang X, Qin K, Qin Y, Shi X, Cong P, Mo D, Liu X, Chen Y, He Z, Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models. Front Genet. 2020;11:138
1	J:215310 Sun W, Wilhelmina Aalders T, Oosterwijk E, Identification of potential bladder progenitor cells in the trigone. Dev Biol. 2014 Sep 1;393(1):84-92
1*	J:154912 Suzuki H, Sada A, Yoshida S, Saga Y, The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol. 2009 Dec 15;336(2):222-31
1	J:123269 Tachibana M, Nozaki M, Takeda N, Shinkai Y, Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J. 2007 Jul 25;26(14):3346-59
1*	J:143535 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J, Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol. 2009 Jan 1;325(1):238-48
1	J:332220 Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M, Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A, Kanai-Azuma M, Kudo A, Kanai Y, SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse. Nat Commun. 2022 Dec 21;13(1):7860
1	J:175037 Urbanek K, Cabral-da-Silva MC, Ide-Iwata N, Maestroni S, Delucchi F, Zheng H, Ferreira-Martins J, Ogorek B, D'Amario D, Bauer M, Zerbini G, Rota M, Hosoda T, Liao R, Anversa P, Kajstura J, Leri A, Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart. Circ Res. 2010 Aug 6;107(3):429-41
1*	J:210584 van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marban E, Molkentin JD, c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
1*	J:18378 van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R, Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994 Nov 15;8(22):2691-703
1	J:274101 Vandenberghe P, Hague P, Hockman SC, Manganiello VC, Demetter P, Erneux C, Vanderwinden JM, Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST). Oncotarget. 2017 Jun 20;8(25):41026-41043
1	J:217603 Vanhoutteghem A, Messiaen S, Herve F, Delhomme B, Moison D, Petit JM, Rouiller-Fabre V, Livera G, Djian P, The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014 Nov;141(22):4298-310
1	J:298691 Wanigasuriya I, Gouil Q, Kinkel SA, Tapia Del Fierro A, Beck T, Roper EA, Breslin K, Stringer J, Hutt K, Lee HJ, Keniry A, Ritchie ME, Blewitt ME, Smchd1 is a maternal effect gene required for genomic imprinting. Elife. 2020 Nov 13;9:e55529
1	J:45265 Ward SM, Harney SC, Bayguinov JR, McLaren GJ, Sanders KM, Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis. J Physiol. 1997 Nov 15;505(Pt 1):241-58
1	J:341688 Xie X, Sun L, Duan Y, Lv Z, Yao X, Wang C, Chen X, Tian S, Yan L, Shao Y, Luo H, Liu J, SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
1	J:91146 Yamatani H, Sato Y, Fujisawa H, Hirata T, Chronotopic organization of olfactory bulb axons in the lateral olfactory tract. J Comp Neurol. 2004 Jul 19;475(2):247-60
1*	J:18760 Yamazaki M, Tsujimura T, Morii E, Isozaki K, Onoue H, Nomura S, Kitamura Y, C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression. Blood. 1994 Jun 15;83(12):3509-16
1	J:256252 Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ, A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo. Cell Rep. 2017 May 9;19(6):1257-1267
1	J:39795 Yoshida H, Takakura N, Kataoka H, Kunisada T, Okamura H, Nishikawa SI, Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development. Dev Biol. 1997 Apr 1;184(1):122-37
1	J:318860 Yoshimura N, Motohashi T, Aoki H, Tezuka K, Watanabe N, Wakaoka T, Era T, Kunisada T, Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin. Dev Growth Differ. 2013 Feb;55(2):270-81
1*	J:154859 Zhou R, Niwa S, Homma N, Takei Y, Hirokawa N, KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Cell. 2009 Nov 13;139(4):802-13